home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3266.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
36 lines
Document 3266
DOCN M94A3266
TI Probably reasons of hypervariability by AIDS.
DT 9412
AU Deichman AM; Cancer Research Centre, Moscow, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):115 (abstract no. PA0080). Unique
Identifier : AIDSLINE ICA10/94369309
AB OBJECTIVE: Any information (especially new) about AIDS is important.
There aren't whole universal picture (even scetch) about nature,
reasons, mechanisms for hypervariability formation by AIDS in biopshere.
METHODS: theoretical reseaches show the main mechanisms of hypothetical
concept may be two: IERT-individual epitope reverse translation (when
there are non-single aminonucleic correspondence for genetic
code--including mutations of different genes); and transfer of special
vector-like nucleic sequences (VLNS-transfer) with nucleic equivalent of
concrete epitope into. RESULTS: we know specific immune responce need
the cognate physical contact between antigenpresentative cell
(macrophage) and T-help, T-T and T-B cell's analogic contacts.
DISCUSSION: supposedly both mechanisms are used by immune responce.
Cross of strategic ways (in the same cells macrophages, T-help,
anothers) for immune responce formation and viruse spreading (the
first); and use the same hypothetical mechanisms (IERT and
VLNS-transfer-the second) probably lead to hypervariability by AIDS.
This mechanisms perhaps can exploit for diversity formation by different
normal and pathologic processes (antibody formation, drug resistance,
etc.).
DE Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY/ MICROBIOLOGY
Antigenic Determinants/GENETICS B-Lymphocytes/IMMUNOLOGY Human
HIV/GENETICS/IMMUNOLOGY HIV Antigens/GENETICS Macrophages/IMMUNOLOGY
Models, Biological T-Lymphocytes/IMMUNOLOGY Translation, Genetic
Variation (Genetics) MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).